Archive

Posts Tagged ‘technology’

Meet its sleek new rival: A350 XWB


.cnn_html_media_utility::before{color:red;content:’’;font-size:9px;line-height:12px;padding-right:1px}
.cnnstrylccimg640{margin:0 27px 14px 0}
.captionText{filter:alpha(opacity=100);opacity:1}
.cnn_html_slideshow_media_caption a,.cnn_html_slideshow_media_caption a:visited,.cnn_html_slideshow_media_caption a:link,.captionText a,.captionText a:visited,.captiontext a:link{color:outline:medium none}
.cnnVerticalGalleryPhoto{margin:0 auto;padding-right:68px;width:270px}
]]

Who's a pretty boy then? Airbus' first completed A350 XWB is unveiled with a full paint-job in Toulouse, France on May 13. The plane is set to rival Boeing's 787 Dreamliner in the mid-size aircraft market. Who’s a pretty boy then? Airbus’ first completed A350 XWB is unveiled with a full paint-job in Toulouse, France on May 13. The plane is set to rival Boeing’s 787 Dreamliner in the mid-size aircraft market.

After completion of painting, Airbus' first A350 XWB will begin final testing in advance of its maiden flight. The plane is built to cruise at a speed of Mach 0.85After completion of painting, Airbus’ first A350 XWB will begin final testing in advance of its maiden flight. The plane is built to cruise at a speed of Mach 0.85

Over 50% of the aircraft's body is made from composite materials. Over 50% of the aircraft’s body is made from composite materials.

The internal cabin width of the aircraft is 5.61 meters, with the A350-1000 seating up to 350 people.The internal cabin width of the aircraft is 5.61 meters, with the A350-1000 seating up to 350 people.

The company says that it will use 25% less fuel compared to current long-range competitor. The company says that it will use 25% less fuel compared to current long-range competitor.

The company has 616 orders for the plane. The company has 616 orders for the plane.

The nose section of the A350 XWB is made with 5% titanium.The nose section of the A350 XWB is made with 5% titanium.

A mock-up of a potential interior on board the aircraft. A mock-up of a potential interior on board the aircraft.


1


2


3


4


5


6


7


8


9

(CNN)Airbus has showed off its new A350 XWB, rolling out its first flyable plane on Monday fresh from the paintshop in company livery.

The aircraft is the first in a family of super efficient passenger planes Airbus designed to go head-to-head against rival Boeing’s 787 Dreamliner and 777s.

“XWB” means “extra wide body.” There are three members in the A350 family: the A350-800, the A350-900 and the A350-1000, which seat 270, 314 and 350 passengers respectively, in three-class seating.

The largest of the three lightweight carbon-composite aircraft, the A350-1000, is 73.88 meters long and has a range of approximately 8,400 nautical miles, or 15,600 kilometers. The catalog price is US$320.6 million. As of March 31, there were 110 orders for the A350-1000 among a total of 616 orders from 34 customers. Most orders, 414, have been for the A350-900.


Click to expand: A350 v Boeing 787 Click to expand: A350 v Boeing 787


Click to expand: A350 v Boeing 787Click to expand: A350 v Boeing 787

The plane unveiled on Monday at Airbus HQ in Toulouse, France is the latest milestone in what has been a turbulent production history for the A350.

Critics have said the A350 program — first launched in 2007 — was a poorly-designed, hasty response to Boeing’s 787.

Dreamliner battery fix: Behind the scenes

“The company, which was hip-deep in sorting out A380 development, simply hadn’t foreseen the huge pent-up demand for a more efficient 250-seat airliner, and tried to take the easy way out by offering a re-engined version of its A330,” aviation journalist David Kaminski-Morrow, air transport editor of Flightglobal.com, told CNN in an earlier report.

Airbus reworked the design, configurations and technology to increase the plane’s range and efficiency.

The unveiled plane, which Airbus have tagged “MSN001,” will undergo final tests before its maiden flight expected in June.

Airbus said it took less than a week to complete the aircraft painting. Last month, engines were installed, ground vibration tests and flight test instrumentation verification were completed.

Read more: What does the A350 mean for travelers?

Article source: http://edition.cnn.com/2013/05/14/travel/airbus-a350-paint/index.html?eref=edition

Article source: http://feedproxy.google.com/~r/NewsRipplesWeb/~3/vW_tZI-uzE4/meet-its-sleek-new-rival-a350-xwb

Categories: Uncategorized Tags:

Former Valve staffers unveil CastAR

Former Valve staffers unveil CastAR

The Technical Illusions CastAR system combines projectors, a camera, shutter glasses and more to create an immersive augmented reality system.


A pair of former Valve employees have announced the formation of a new company dedicated to one thing: bringing to market the augmented reality technology they were hoping to develop for Valve’s hardware arm.

Hackers Jeri Ellsworth and Rick Johnson, formerly employed by Valve prior to the layoffs in February that saw 25 employees leave the company, have launched the company Technical Illusions with a view to releasing a system of augmented reality gaming devices called CastAR.

Unveiled at the Maker Faire in San Mateo this weekend, and written up by Make, the project uses LCD-shutter glasses with two tiny projectors mounted on them to produce a virtual reality environment that is projected wherever the wearer is looking.

The system works by having the viewer peer through the glasses at a specially-constructed retro-reflective panel edged with infra-red LEDs. The projectors, one mounted over each lens, send out the augmented reality images while the shutter glasses work to ensure that each eye only receives images from its own projector – creating the illusion of depth. Finally, the webcam – mounted on the nose-bridge of the glasses – tracks the LEDs to allow the system to adjust the projected images according to the motion of the user’s head, in a similar manner to the famous 3D demos created by Johnny Chung Lee using Nintendo Wiimotes.

The result: the reflective surface becomes a window into a virtual 3D world, with users able to move around a virtual objects, peering round its corners to view areas that would otherwise be invisible. The head-tracking system can also be used to directly control a game, with visitors to the Technical Illusions tent at the event being treated to a flying game. Accessories are also in development, with an LED mounted on the end of a chopstick creating a ‘magic wand’ that allows the user to play a Jenga-like title and RFID-enabled playing cards already in the prototype stage. The system even allows for multiplayer gaming on a single surface, ensuring that users only see their own perspective.

These demos are the start and the glasses are early prototypes,‘ the pair have announced. ‘Each system not only lets you play, but also includes a complete development kit. You can get up and running quickly using our simple scripting language, or go as deep as you want by connecting our API to your game. And don’t worry, this is an open platform. If you make something, you can give it away or sell it anywhere you want.

As with most such projects, CastAR combines a series of existing products into a single, innovative creation: a pair of liquid-crystal shutter glasses, familiar to anyone with an active 3D monitor or TV, is combined with two pico-projectors, a reflective surface, a small webcam and a shedload of infra-red LEDs to create a highly complex new creation.

It is this complexity that is likely to be the major barrier to the technology taking off. In particular, the requirement for a retro-reflective surface (one that aims the reflection straight back at you) makes this technology unusable in a normal living room, for instance. However, it could be used in a “holo-deck” type environment where the walls and ceiling are covered in reflective material and the user – indeed multiple users – are able to navigate a virtual world.

Thus fair, Technical Illusions has not provided a release date or pricing for the hardware.

Article source: http://feedproxy.google.com/~r/bit-tech/news/~3/p27qo5zY-KM/1


Article source: http://feedproxy.google.com/~r/GamingRipplesWeb/~3/gNZbf7U34FY/

Categories: Uncategorized Tags:

EKWaterBlocks responds to Aquatuning licence claims

EKWaterBlocks responds to Aquatuning licence claims

The EK Supreme waterblock is at the centre of the dispute with its jet-microfins also appearing on competitors products


EKWaterBlocks has released a statement in response to Aquatuning’s recent claims that is hasn’t paid licence fees for various products.

The water-cooling hardware manufacturer claims much of the technology that was under licence was already in use by other companies that weren’t paying royalties but were still allowed to sell through Aquatuning’s webshops.

It also cites that it has invested its own time and money in development of newer models, while regretting Aquatuning’s decision to stop selling its products and apologising to customers, and promises new and exciting products in the future.

We’re keen to stay on the sidelines for obvious reasons but the press release reads as follows:

Yesterday on the 17th of May 2013, Aquatuning went public with a press release regarding EKWB. EKWB feels obliged to share more information on that subject to put things into the right perspective.

Regarding development of many products:

EKWB has a know-how agreement with Aquatuning with annexes for three products on it (EK Supreme, EK Supreme LT, EK-BAY Spin Reservoir). One is still effective and EKWB is paying fees. Procedures regarding products were as follows:

1. EK Supreme: The know-how that EKWB got for EK Supreme was a simple drawing done while meeting with Aquatuning. The drawing included basic principle of »jet-microfins«. All research and development to make the EK-Supreme the number one CPU waterblock on the market at that time was done by EKWB in the following eight months. As we realized only after signing the agreement, similar products were already on the market, so the principle was nothing new. Please see product 1 from year 2005, and product 2, product 3 and product 4 from even more recent time frames. EKWB had been paying fees as agreed upon for more than 3 years.

2. EK Supreme LT: In the meantime, EKWB developed further EK Supreme models with their own resources. Supreme LT, which is quite a side step from original EK-Supreme, was developed entirely in EKWB RD. The concept of simple micro-fins was also around before this time. As EKWB went with the name Supreme LT, EKWB took its own initiative and signed annex to the agreement.

3. EK-BAY Spin Reservoir: Annex for EK-BAY Spin Reservoir was also signed after a drawing with the basic principles. It is still currently effective.

Regarding critical events in cooperation:

Aquatuning started to sell products from competitors which were using the same cooling engine »jet-microfins«, that EKWB was paying know-how fees to Aquatuning. There were numerous attempts from management team of EKWB to somehow resolve discrepancy with no avail. Furthermore, Aquatuning went on and copied the EK Reservoir: EK-MULTIOPTION RES Rev 2. – Aquatuning Phobya Balancer. EKWB sent inquiries regarding know-how fees on this product to Aquatuning, but the answer from Aquatuning was that there are many reservoirs that look nearly the same.

After EKWB finished the contract, Aquatuning began to sell their own UC-1 CPU Water Block made on the principles of »jet-microfins«. After that, Aquatuning pressed EKWB for royalties. As of December 2012, Aquatuning almost totally stopped with orders. Contradictory to this, Aquatuning continued putting new EKWB products on their site with delivery dates, even though there were no orders for those items. Aquatuning also put delivery dates of EKWB products that were out of stock, and not re-ordered from EKWB. As this situation was becoming a bit strange with no orders and goods and dates on Aquatuning site, EKWB asked Aquatuning to start ordering again or stop ordering at all.

Today’s press release is a conclusion to this matter. EKWB’s intention was never to terminate the contract. EKWB just wanted both parties to stick to the same principals. We regretfully have accepted the decision of Aquatuning. We apologize that our users and fans have been bothered with this event, this is EKWB’s first and last press release on this subject. We are looking forward to sharing exciting and new products coming in the near future from EKWB.

What do you make of the story? Let us know in the forum.

Article source: http://feedproxy.google.com/~r/bit-tech/news/~3/zwcIzGfz_y4/1


Article source: http://feedproxy.google.com/~r/GamingRipplesWeb/~3/uTvShrU2ZgE/

Categories: Uncategorized Tags:

5 things to know about Dreamliner’s return


.cnn_html_media_utility::before{color:red;content:’’;font-size:9px;line-height:12px;padding-right:1px}
.cnnstrylccimg640{margin:0 27px 14px 0}
.captionText{filter:alpha(opacity=100);opacity:1}
.cnn_html_slideshow_media_caption a,.cnn_html_slideshow_media_caption a:visited,.cnn_html_slideshow_media_caption a:link,.captionText a,.captionText a:visited,.captiontext a:link{color:outline:medium none}
.cnnVerticalGalleryPhoto{margin:0 auto;padding-right:68px;width:270px}
]]

Boeing's 787 Dreamliner got off to a rough start. Just over a year after its first commercial flight, the aircraft was grounded after batteries overheated on two flights. This Dreamliner, built for Air India, was the first produced at Boeing's new production facilities in North Charleston, South Carolina.Boeing’s 787 Dreamliner got off to a rough start. Just over a year after its first commercial flight, the aircraft was grounded after batteries overheated on two flights. This Dreamliner, built for Air India, was the first produced at Boeing’s new production facilities in North Charleston, South Carolina.

Aviation safety regulators have approved Boeing's battery fixes, and Dreamliners have started to fly again. Earlier this year, this All Nippon Airways 787 made an emergency landing because of battery troubles. ANA plans to resume commercial Dreamliner flights in June.Aviation safety regulators have approved Boeing’s battery fixes, and Dreamliners have started to fly again. Earlier this year, this All Nippon Airways 787 made an emergency landing because of battery troubles. ANA plans to resume commercial Dreamliner flights in June.

The redesigned battery system, right, adds a containment and venting system to prevent possible overheating from affecting the plane. At left is a battery case damaged during a flight on a Japan Airlines Boeing 787. It was one of two incidents that prompted the Dreamliner's grounding.The redesigned battery system, right, adds a containment and venting system to prevent possible overheating from affecting the plane. At left is a battery case damaged during a flight on a Japan Airlines Boeing 787. It was one of two incidents that prompted the Dreamliner’s grounding.

A LOT Polish Airlines 787, with a redesigned lithium-ion battery system, performs a test flight in March at Paine Field in Everett, Washington. The Dreamliner's distinctive wings sweep back at 32 degrees.A LOT Polish Airlines 787, with a redesigned lithium-ion battery system, performs a test flight in March at Paine Field in Everett, Washington. The Dreamliner’s distinctive wings sweep back at 32 degrees.

United Airlines is the lone U.S. carrier flying the Dreamliner. These are Business First Class seats on one of United's six 787s.United Airlines is the lone U.S. carrier flying the Dreamliner. These are Business First Class seats on one of United’s six 787s.

The use of composite materials on the Dreamliner makes larger window cutouts possible. Composites have replaced aluminum as the predominant material in the 787. The 777 is made up of 50% aluminum and 12% composites, compared with the Dreamliner's nearly 50% makeup of composites and just 20% aluminum.The use of composite materials on the Dreamliner makes larger window cutouts possible. Composites have replaced aluminum as the predominant material in the 787. The 777 is made up of 50% aluminum and 12% composites, compared with the Dreamliner’s nearly 50% makeup of composites and just 20% aluminum.


1


2


3


4


5


6

Editor’s note: CNN’s Thom Patterson boards the 787 Dreamliner Monday for its first commercial U.S. domestic flight after it was grounded for battery problems. Watch for his report this afternoon on CNN.com and follow his progress on Twitter.

(CNN) — Aviation fans have already named it Dreamliner 2.0.

No longer grounded for safety concerns, Boeing’s embattled 787 Dreamliner now has a few things to prove. Monday might be a good day to start. That’s when domestic Dreamliner flights return to America’s airways.

At 11 a.m., United Flight 1 is scheduled to depart Houston’s George Bush Intercontinental Airport for Chicago’s O’Hare International Airport. The airline plans to roll out additional 787 flights throughout the week. Some international carriers have already resumed Dreamliner service.

For aviation enthusiasts it’s kind of a big deal. As word spreads of Dreamliner’s return, travel advisers report they’re getting calls from curious fliers looking to connect with one of United’s six 787s at Dreamliner hubs.


The Dreamliner can do THAT?


Why the FAA grounded Dreamliner


Dreamliner probe aimed at reliability


Are lithium ion batteries safe?


Dreamliner catches fire at airport

They want a chance to ride the 787 and experience its fancy interior lighting, high-tech windows and mysterious anti-turbulence technology. So far, United is the only U.S. carrier flying the aircraft

Dreamliner interactive: The Boeing 787 layout

This plane is so lightweight that it can fly farther with the same amount of fuel as heavier airliners. It can carry 200-plus passengers a third of the way around the globe. Boeing says the plane’s increased profitability will open more destination cities for travelers.

Industry observers are curious to see what the future holds for Dreamliner, the first entire airline model to be grounded by the Federal Aviation Administration in more than 30 years.

Lithium-ion batteries that overheated on two Dreamliners in January prompted authorities to ground all 50 787s worldwide, but a redesigned battery system has cleared the way for the plane’s return.

Here are five things about Dreamliner for American travelers to keep in mind now that it’s back in service:

How safe is it?

“It’s a safe airliner to get back on and fly,” says Capt. Kevin Hiatt, president of the Flight Safety Foundation, an independent aviation safety think tank. The FAA simply exercised an abundance of caution when it grounded the aircraft, he says. What travelers should take away from the grounding is “the fact that we’ve got a pretty good system that works.”

Still, now that all eyes are on Dreamliner in the wake of the grounding, new reports of even minor glitches are likely to make travelers nervous.

Japanese airline ANA reported an incident that damaged an electrical distribution panel on a Dreamliner test flight on May 4. ANA blamed it on a nut that had not been properly tightened, calling it a “minor issue” unrelated to batteries.

A team made up of experts from Boeing and from outside the company redesigned the battery system, which separates, insulates and ventilates the battery cells. Passenger rights advocates have screamed “conflict of interest” about the FAA’s longstanding policy allowing Boeing to certify components of its own aircraft. They’re calling for more independent testing and analysis of Dreamliner’s battery fix. But Hiatt says the process is safe and as independent as possible.

“Looking at historical data, we haven’t had any evidence over the years that self-certification has been responsible for any problems,” says John Goglia, a former member of the National Transportation Safety Board, the federal air crash investigation agency.

Travelers have such high regard for the safety of the U.S. aviation system they don’t pay much attention to the kind of plane they’re flying, says Brett Snyder, travel adviser and self-described “president and chief airline dork” of CrankyFlier.com. Most aren’t worried about flying the 787, but if Dreamliner develops another problem “then that might change things.”

Goglia, who also worked for years as an airline mechanic, warns that a repeat incident with the batteries “would severely impeach Boeing’s engineering capabilities.” Success for the Dreamliner heavily relies on no repeats, Goglia says.

How’s its reputation?

When an aircraft is hit by the first FAA grounding order for an entire airliner type in three decades, does it come with a stigma? “They’re definitely going to have some lumps in the road because of that,” says Goglia.

On the other hand, Snyder believes the “average everyday traveler isn’t looking at the specific aircraft type. They’re looking at the flight times and they’re looking at the prices.”

“I’m sure there are some people that are feeling like they don’t want to get on it,” says Snyder. “They’ll probably feel that way in the short term until the Dreamliner develops a “track record of being reliable and safe.”

CNN.com readers have mixed feelings about the new plane.

“If there are no further incidents absolutely no one is going to remember this in a year or two,” wrote one commenter. “Other troubled airplanes like the DC-10 actually killed people and still went on to be successes.”

Another isn’t so optimistic: “I fly between continents 1-2 times per year and have done so for the last decade and I will NEVER set foot on a Dreamliner.”

How does it feel?

We’ll soon find out for ourselves when we fly United Flight 1 today, but supposedly, Dreamliner air is rare up there.

New cabin environmental systems allow control of air pressure and humidity.

Dreamliner’s cabin pressure is set to the equivalent of 6,000 feet above sea level — compared to the traditional setting of 8,000 feet. Feeling like you’re at a lower altitude lets the body absorb more oxygen, making passengers less susceptible to airsickness. Humidity in the cabin is supposed to feel more comfortable, too.

Everybody talks about the windows. By pushing a button under each one, it activates energized gel embedded in the windowpane, which darkens or lightens the glass. No shades necessary.

Check back here with CNN.com today and we’ll let you know what these tech-laden features are really like.

How does it ride?

It’s a mystery how it works, but the Dreamliner comes equipped with gust suppression technology that is designed to smooth the ride during moderate turbulence. Boeing is keeping its cards close to the vest. Suffice it to say sensors on the aircraft respond to turbulence and send command signals that adjust parts of the wings. Result: smoother flying, says Boeing. We’ll check it out for ourselves.

“It looks pretty awesome, although I’d just rather not have turbulence — then you don’t need the gust suppression,” jokes Snyder. “But I think it will be interesting to see how that feels, and how the plane handles it.”

How did we get here?

Boeing used to think airlines felt a need for speed.

But the company soon learned it had miscalculated. What the airlines really wanted was efficiency, triggering a trend toward fuel-sipping, lightweight, long-range airliners.

Here’s what happened: In the early 2000s, Boeing was brainstorming the next generation of airliners — the first that would be built largely from lightweight carbon-composite materials.

These new planes would jet across the nation at about 650 mph — nearly the speed of sound. They called this idea the Sonic Cruiser.

But as oil prices rose, the Sonic Cruiser took a dive. Boeing abandoned the concept, keeping the idea of a new lightweight, carbon-composite airliner. Speed was out, efficiency in. By 2003, the project had a name: Dreamliner.

This year, Boeing’s rival Airbus will follow Dreamliner with its A350 XWB, another sleek, long-distance fuel-sipper that can carry 200-plus passengers.

Related story: Airbus rolls out sleek, new A350 XWB

CNN’s Thom Patterson boards Boeing’s Dreamliner later today for its first domestic flight on a U.S. carrier after it was grounded earlier this year. Check back for updates later today and follow his progress on Twitter.


Article source: http://edition.cnn.com/2013/05/20/travel/dreamliner-returns/index.html?eref=edition

Article source: http://feedproxy.google.com/~r/NewsRipplesWeb/~3/FoasnuudF8Q/5-things-to-know-about-dreamliners-return

Categories: Uncategorized Tags:

EKWaterBlocks repsonds to Aquatuning licence claims

EKWaterBlocks repsonds to Aquatuning licence claims

The EK Supreme waterblock is at the centre of the dispute with its jet-microfins also appearing on competitors products


EKWaterBlocks has released a statement in response to Aquatuning’s recent claims that is hasn’t paid licence fees for various products.

The water-cooling hardware manufacturer claims much of the technology that was under licence was already in use by other companies that weren’t paying royalties but were still allowed to sell through Aquatuning’s webshops.

It also cites that it has invested its own time and money in development of newer models, while regretting Aquatuning’s decision to stop selling its products and apologising to customers, and promises new and exciting products in the future.

We’re keen to stay on the sidelines for obvious reasons but the press release reads as follows:

Yesterday on the 17th of May 2013, Aquatuning went public with a press release regarding EKWB. EKWB feels obliged to share more information on that subject to put things into the right perspective.

Regarding development of many products:

EKWB has a know-how agreement with Aquatuning with annexes for three products on it (EK Supreme, EK Supreme LT, EK-BAY Spin Reservoir). One is still effective and EKWB is paying fees. Procedures regarding products were as follows:

1. EK Supreme: The know-how that EKWB got for EK Supreme was a simple drawing done while meeting with Aquatuning. The drawing included basic principle of »jet-microfins«. All research and development to make the EK-Supreme the number one CPU waterblock on the market at that time was done by EKWB in the following eight months. As we realized only after signing the agreement, similar products were already on the market, so the principle was nothing new. Please see product 1 from year 2005, and product 2, product 3 and product 4 from even more recent time frames. EKWB had been paying fees as agreed upon for more than 3 years.

2. EK Supreme LT: In the meantime, EKWB developed further EK Supreme models with their own resources. Supreme LT, which is quite a side step from original EK-Supreme, was developed entirely in EKWB RD. The concept of simple micro-fins was also around before this time. As EKWB went with the name Supreme LT, EKWB took its own initiative and signed annex to the agreement.

3. EK-BAY Spin Reservoir: Annex for EK-BAY Spin Reservoir was also signed after a drawing with the basic principles. It is still currently effective.

Regarding critical events in cooperation:

Aquatuning started to sell products from competitors which were using the same cooling engine »jet-microfins«, that EKWB was paying know-how fees to Aquatuning. There were numerous attempts from management team of EKWB to somehow resolve discrepancy with no avail. Furthermore, Aquatuning went on and copied the EK Reservoir: EK-MULTIOPTION RES Rev 2. – Aquatuning Phobya Balancer. EKWB sent inquiries regarding know-how fees on this product to Aquatuning, but the answer from Aquatuning was that there are many reservoirs that look nearly the same.

After EKWB finished the contract, Aquatuning began to sell their own UC-1 CPU Water Block made on the principles of »jet-microfins«. After that, Aquatuning pressed EKWB for royalties. As of December 2012, Aquatuning almost totally stopped with orders. Contradictory to this, Aquatuning continued putting new EKWB products on their site with delivery dates, even though there were no orders for those items. Aquatuning also put delivery dates of EKWB products that were out of stock, and not re-ordered from EKWB. As this situation was becoming a bit strange with no orders and goods and dates on Aquatuning site, EKWB asked Aquatuning to start ordering again or stop ordering at all.

Today’s press release is a conclusion to this matter. EKWB’s intention was never to terminate the contract. EKWB just wanted both parties to stick to the same principals. We regretfully have accepted the decision of Aquatuning. We apologize that our users and fans have been bothered with this event, this is EKWB’s first and last press release on this subject. We are looking forward to sharing exciting and new products coming in the near future from EKWB.

What do you make of the story? Let us know in the forum.

Article source: http://feedproxy.google.com/~r/bit-tech/news/~3/zwcIzGfz_y4/1

Article source: http://feedproxy.google.com/~r/GamingRipplesWeb/~3/NF39LNgE1js/

Categories: Uncategorized Tags:

Stem cell cloning explained

(CNN) — A human embryo, containing about a couple hundred cells, is smaller than the period at the end of a sentence. Scientists need strong microscopes to see these precursors to life, and to take from them stem cells, which have the potential to become any cell in the body.

Earlier this week a breakthrough in this field was announced. A group of researchers published in the journal Cell proof that they had created embryonic stem cells through cloning. The scientists produced embryos using human skin cells, and then used the embryos to produce stem cell lines.

“It is an incredibly powerful approach with potential to generate almost any tissue in the body, genetically identical to the patient,” said Jeff Karp, associate professor at Harvard Medical School and co-director of the Center for Regenerative Therapeutics at the Brigham and Women’s Hospital in Boston.

Creating an embryo just from an egg and a skin cell seems like magic, but just how practical would the subsequent stem cells be? And does it actually amount to cloning?

What they did

Normally, an embryo is created when sperm enters the egg and it starts to divide. But, in the Cell study, Shoukhrat Mitalipov and colleagues at Oregon Health Science University began with skin cells from an 8-month-old baby that had a genetic disease. They did not use sperm.

To create each embryo, they took the DNA out of an egg, so that it was hollow, and replaced it with the skin cell’s DNA instead. The baby’s DNA was the only genetic material being used.

With the help of chemicals, the egg started to divide just like a normal fertilized egg would. Then, within several days, embryos genetically identical to the baby were created, from which stem cells were derived.


Understanding the stem cell breakthrough


Indian clinic’s stem cell therapy real?


Heart stem cells repair muscle damage

Embryonic stems research is inherently controversial because in order to use the stem cells for science, the embryo, which is a collection of cells that could develop into a fully formed human, is destroyed, even though embryos in these procedures are left over from in vitro fertilization.

However, Mitalipov said the embryos created in his study, from skin cells and eggs, would not grow babies. That would have required additional technology, and it wasn’t part of the study.

While cloning stem cells is a technical breakthrough, there’s already a method of deriving embryonic-like stem cells that doesn’t require the use of embryos at all: induced pluripotent stem (IPS) cells, said Dr. George Daley, who is director of the Stem Cell Transplantation Program at Children’s Hospital Boston and an international expert in stem cells.

Induced pluripotent stem cells can come from any cell in the human body, including skin cells, so they don’t have the moral quandaries surrounding them. Researchers have developed methods of inserting genes to “turn back the clock” on cells that have already specialized, so that they can turn into anything again. It doesn’t matter what the cell was before; it can now be reprogrammed as any kind of cell researchers want.

The new study involves a complex method that requires women to donate eggs, and a demanding manipulation of cell components on a tiny scale, Daley said.

What remains to be seen is whether these cloned embryonic stem cells are more useful therapeutically than the noncontroversial induced pluripotent stem cells, and questions linger about their effectiveness.

What’s the best type of stem cell

Ethical questions aside, researchers say they need to explore both embryonic and induced pluripotent stem cells in order to see what works best for various diseases and conditions.

Safety concerns linger around induced pluripotent stem cells because they were first created inserting four new genes.

“Remember, this was a genetic manipulation that was done to generate those cells, and there is concern that (for) anything you derive from them and you put back in the patient as graft, you may be at risk,” said John Gearhart, director of the Institute for Regenerative Medicine at the University of Pennsylvania, and one of the leading pioneers of stem cell research.

This image shows the donor egg cytoplasm, the substance that fills the cell, with the nucleus of the skin cell.

New techniques have been developed, however, to make induced pluripotent stem cells without permanent genetic modifications that were associated with tumors.

In mice, Daley and colleagues have shown that stem cells derived from the nuclear transfer of cells to make embryos — the technique described in Mitalipov’s paper — were indeed closer to natural embryo stem cells than induced pluripotent stem cells. The differences were so subtle that they may not be meaningful, however, he said.

Is it cloning?

The new study involves something similar to the cloning technique that led to the birth of Dolly, the famous cloned sheep that was born in July 1996. But making embryos for reproduction would require more advanced, complex techniques than were used in the new study — and serious scientists do not endorse human cloning for reproduction.

Mitalipov, senior author on the paper, laughs when asked if he wants to clone a person. “No, of course not,” he said.

“We tried the same approach to clone monkeys, because we’d been interested for biomedical research to produce cloned monkeys, and it never worked,” he said. “We’ve been working for a decade in that area.”

Mitalipov and colleagues had no intention of this research leading to the birth of a cloned human.

Researchers say there have been so many health problems in cloned animals, including Dolly herself, that it would not be ethical to attempt to create a cloned human.

“No legitimate scientist would be stepping forward to apply this in reproductive cloning, or for fertility work,” Daley said. “I would argue that really there are no good medical reasons to generate a cloned baby.”

So what is it good for?

There’s one important area where experts say Mitalipov’s method could have tremendous implications: Mitochondrial disease.

The mitochondria are the “power plants” of cells, supplying them with chemical energy. DNA in the mitochondria is inherited entirely from the mother’s egg, unlike the DNA in the cell’s nucleus, which comes from both parents.

Mutations in mitochondrial DNA can lead to deadly diseases, and their associated mutations are passed down to each new generation. Induced pluripotent stem cells preserve these harmful mutations, says Mitalipov.

A cell’s mitochondrial DNA develops mutations over the course of a lifetime, little by little, and may result in diseases such as Parkinson’s disease and diabetes, Mitalipov said. It’s possible, he says, that one day there will be stem cell treatments for aging and age-related diseases.

The only way to ensure that stem cells derived from an adult patient do not have mitochondrial DNA mutations would be to use the technique demonstrated in the new study, Mitalipov said: Creating embryos with cells from the patient’s own body, and healthy eggs, for the purpose of deriving embryonic stem cells.

“You want 0 miles in (the) rejuvenated cells that you want to put back into these patients,” he said. “The 0 mileage engine is in the egg.”

Mitalipov’s group also demonstrated in a 2012 Nature study that it could be possible to, using genetic techniques, reconstruct embryos that would not have the unhealthy mitochondrial mutations. This is not cloning, but draws on similar knowledge, and could cure a family’s genetic disease lineage in the future.

What’s next?

Daley estimates human clinical trials in stem cells will start within one to three years, but perhaps it could take a decade or more before the impact of stem cell therapy becomes widespread.

Gearhart is confident that the more we learn how to manipulate stem cells safely, there will be safe way to provide them to patients who need them. But there are different levels of risk for different uses. There will always be a risk-benefit calculation to be made, he said.

Different areas of stem cell research have proven to be harder than others. Beta cells for type I diabetes have been “a very difficult nut to crack,” Gearhart said, but there have been promising developments in repairing the heart, something that his lab has worked on, as well as for eye diseases.

“I think it’s going to be exciting times over the next several years when it comes to this,” he said.


Article source: http://edition.cnn.com/2013/05/18/health/stem-cells-cloning/index.html?eref=edition

Article source: http://feedproxy.google.com/~r/NewsRipplesWeb/~3/PXG4yXrjx_4/stem-cell-cloning-explained

Categories: Uncategorized Tags:

Coming era of driverless cars

Editor’s note: CNN contributor Andrew Keen organized and hosted an invitation-only Silicon Valley event called FutureCast. A group of entrepreneurs, investors, technologists and writers discussed the impact of the digital revolution on transportation. All this week CNN Business Traveller will bring you highlights from the debate. ATT and Ericsson hosted the conference at the ATT Foundry in Palo Alto.

(CNN) — Does the future of transportation really mean the end of driving?

At the inaugural FutureCast event many of Silicon Valley’s most innovative entrepreneurs and thinkers believed it could be.

Yes, they said, these intelligent cars are for real and the future has arrived in the shape of collision-proof, driverless automobiles.

“Seven U.S. states have legalized driverless vehicles now,” said David Frigstad, Chairman of consultancy Frost Sullivan. “The technology works today. We aren’t talking about a flying car. We are talking about a car that works today.”


Transportation confronts its Kodak moment


The future of transportation: Global View


CNN test-drives ‘self-driving car’

The self-driving car will making the whole driving experience much more pleasurable, predicted Brad Templeton, the former chairman of the Electronic Frontier Foundation who has worked extensively with Google on their self-driving car.

“The inside of the car is going to change a lot,” he explained. “Right now, cars are sold by acceleration. Then they are going to be sold by comfort. They’ll be face to face so they’ll be a pleasant experience. You child will say: ‘Mommy are we there already?’ rather than ‘Are we there yet?’”

Read more: Transportation confronts its “Kodak moment”

Even grizzled Silicon Valley entrepreneurs like Reputation.com CEO Michael Fertik confessed to being wowed by the self-driving car.

“Listen, I was driving to work the other day and I saw the self-driving Google car buzz by me driving much better than I think I was,” Fertik said. “I don’t know if the guy had his hands on the wheel. There’s this big whirly thing on the top. It’s like Star Trek.”

Four companies — Audi, Mercedes, BMW and Volvo — will have automated cars in the market in the next 12 months noted The New York Times’ technology writer John Markoff.

“We are about to enter into this great social experiment,” he said.

However not all FutureCast attendees agreed that this social experiment is that great.

“You may sell these cars from Audi, but I have an Audi parked out front,” noted former Best Buy CTO Robert Stephens. “Its Bluetooth doesn’t sync properly with my audio. There’s no frigging way I’m letting this thing drive me down the highway yet.”

But even Stephens is excited by the idea of the self-driving car. “The minute you realize you can be in this thing and surf your email and not touch the car that will be awesome,” he said about a technology which, for better or worse, is about to radically change all of our lives.


Article source: http://edition.cnn.com/2013/05/14/business/bussiness-traveller-futurecast-driverless-car/index.html?eref=edition

Article source: http://feedproxy.google.com/~r/NewsRipplesWeb/~3/rp0Dtc2sCkw/coming-era-of-driverless-cars

Categories: Uncategorized Tags:

Main Sail: ‘React fast or be swept away’


.cnn_html_media_utility::before{color:red;content:’’;font-size:9px;line-height:12px;padding-right:1px}
.cnnstrylccimg640{margin:0 27px 14px 0}
.captionText{filter:alpha(opacity=100);opacity:1}
.cnn_html_slideshow_media_caption a,.cnn_html_slideshow_media_caption a:visited,.cnn_html_slideshow_media_caption a:link,.captionText a,.captionText a:visited,.captiontext a:link{color:outline:medium none}
.cnnVerticalGalleryPhoto{margin:0 auto;padding-right:68px;width:270px}
]]

Sailing around the globe solo is one of the most grueling adventures on the planet. But it also offers a moving experience, unique insight into nature, and survival skills which stay with the sailor for the rest of their lives. What have these brave seafarers learned from their time on the waves?Sailing around the globe solo is one of the most grueling adventures on the planet. But it also offers a moving experience, unique insight into nature, and survival skills which stay with the sailor for the rest of their lives. What have these brave seafarers learned from their time on the waves?

In 2010, Australian sailor Jessica Watson became the youngest person to single-handedly circumnavigate the globe, at just 16-years-old. Staying positive, not letting myself think negatively or sad was a huge asset. Very often it was only when I was upset about something else, that I would feel homesick. And you'd also be surprised what you get used to, after the first week being alone, she told CNN.In 2010, Australian sailor Jessica Watson became the youngest person to single-handedly circumnavigate the globe, at just 16-years-old. “Staying positive, not letting myself think negatively or sad was a huge asset. Very often it was only when I was upset about something else, that I would feel homesick. And you’d also be surprised what you get used to, after the first week being alone,” she told CNN.

I think it was actually the years of work and the mental psyching myself up before the voyage that made me realize more about myself, than the voyage itself. I'd spent so long imagining myself on the voyage and questioning whether I'd really be able to do it, so by the time I was ready to leave I felt confident that I'd be able to. Then it was just a matter of getting on with it, Watson added.“I think it was actually the years of work and the mental psyching myself up before the voyage that made me realize more about myself, than the voyage itself. I’d spent so long imagining myself on the voyage and questioning whether I’d really be able to do it, so by the time I was ready to leave I felt confident that I’d be able to. Then it was just a matter of getting on with it,” Watson added.

Briton Robin Knox-Johnston made history in 1969 as the first person to sail solo, nonstop around the world. In my case, because I was sailing a boat, which requires full concentration, I never really had time to feel lonely for more than a few minutes as there was always something to do, he told CNN.
Briton Robin Knox-Johnston made history in 1969 as the first person to sail solo, nonstop around the world. “In my case, because I was sailing a boat, which requires full concentration, I never really had time to feel lonely for more than a few minutes as there was always something to do,” he told CNN.

In 2007 Knox-Johnston again smashed the record books, this time as the oldest person to circumnavigate the globe, at 68-years-old. Knighted in 1995, Knox-Johnston has also been named UK Yachtsman of the Year three times. I doubt I had been alone for 24 hours before I set out, but once I was sailing, loneliness was not something that I dwelt upon, he said.
In 2007 Knox-Johnston again smashed the record books, this time as the oldest person to circumnavigate the globe, at 68-years-old. Knighted in 1995, Knox-Johnston has also been named UK Yachtsman of the Year three times. “I doubt I had been alone for 24 hours before I set out, but once I was sailing, loneliness was not something that I dwelt upon,” he said.

Former schoolteacher Dee Caffari is the first woman to sail single-handedly nonstop around the world in both directions -- westward in 2006 and eastward in 2009. It is only when I had the opportunity to reflect or I spoke to someone at home that I felt those pangs of isolation. But with a great shore team and so many supporters behind me, I really didn't feel that I was doing it on my own, Caffari told CNN.Former schoolteacher Dee Caffari is the first woman to sail single-handedly nonstop around the world in both directions — westward in 2006 and eastward in 2009. “It is only when I had the opportunity to reflect or I spoke to someone at home that I felt those pangs of isolation. But with a great shore team and so many supporters behind me, I really didn’t feel that I was doing it on my own,” Caffari told CNN.

I was very affected by news of other competitors capsizing or being seriously injured and I suppose hearing about other people having life or death experiences, when they were in exactly the same environment as me, did increase my anxiety. I love what I do and I think you have to focus on the positives in life, otherwise I don't think you would ever leave the house, she said.
“I was very affected by news of other competitors capsizing or being seriously injured and I suppose hearing about other people having life or death experiences, when they were in exactly the same environment as me, did increase my anxiety. I love what I do and I think you have to focus on the positives in life, otherwise I don’t think you would ever leave the house,” she said.


1


2


3


4


5


6


7

Editor’s note: MainSail is CNN’s monthly sailing show, exploring the sport of sailing, luxury travel and the latest in design and technology.

(CNN) — Coming face-to-face with 25-meter waves, spending months on end without human contact, and shrinking your world to the confines of a 10-meter boat.

Who are the superhumans who single-handedly sail around the world?

In many cases they are ordinary people forced to survive in the most extraordinary of circumstances.

Here, three of those record-breaking sailors reveal what they learned from their time on the waves — from coping with loneliness to confronting their own mortality and reaching deep within for inspiration to continue their remarkable journey.

Jessica Watson

At just 16-years-old, Australian schoolgirl Jessica Watson became the youngest person to single-handedly sail nonstop around the world.

She completed the epic seven month journey in 2010, in a 10-meter yacht called Ella’s Pink Spirit.

In 2011, Watson was named Young Australian of the Year and has since written a book on her experience called True Spirit.

CNN: How did you cope with loneliness?

Jessica Watson: From the moment I sailed out of Sydney I missed everyone back home. I wouldn’t just miss family and friends, but also simple things like going for a walk along the beach. But despite missing these things badly, I can honestly say I never felt lonely. Lonely is a Friday night on land when no one has asked you out! It’s somehow different when you’ve chosen to put yourself out there alone.

CNN: What did you discover about yourself?

JW: I learned that you really can achieve anything if you set your mind to it. Before dreaming of sailing around the world I was a scared, shy kid, but it was something I wanted to do enough that I overcame those fears. And these days, on dry land, I’m the biggest wuss again!

CNN: Did it affect your idea of mortality?

JW: I can’t say that voyage affected my idea of mortality. Although it was during one of the most terrifying moments out at sea that I realized how important the people close to me are — not so much being with them, but not wanting to put them through so much hardship.

CNN: What inspired you?

JW: It was the stories of other people who sailed around the world that first put the idea in my head. But it wasn’t so much the adrenalin pumping, adventurous side that appealed to me. As boring as it sounds, it was thinking about how the risks of such a voyage might be minimized and wondering if I really could do it, that had me hooked. Another big part of my motivation was wanting to make people question their perceptions of what a young person or girl is capable of.

Read: Return to waves for Richard Branson’s retro speedboat

CNN: How do you view nature?

JW: When you sit on a boat for 210 days straight with only the very rare glimpse of land, you start to take a lot of notice of nature. One experience I had with a dolphin was a standout. It was during the first storm of the trip, and throughout the worst hours a dolphin swam along next to Pink Lady — a pretty incredible, reassuring presence.

Robin Knox-Johnston

In 1969, Knox-Johnston became the first person to single-handedly sail nonstop around the world.

The yachting legend smashed the record books again in 2006, when at the age of 67 he became the oldest person to circumnavigate the globe solo.

Knighted in 1995, the 74-year-old Londoner is founder of the annual Clipper Round the World Yacht Race for amateur sailors.

Read: The people who quit their jobs to sail in Clipper Race

CNN: Did it affect your idea of mortality?

Robin Knox-Johnston: It certainly did. When you see a 25-meter wave stretching from horizon to horizon, with the top leaning forward and breaking as it rushes towards your boat, you don’t have much time to think. You have to react fast or be swept away. It is afterward, when the wave has swamped over the boat and you emerge wet, shaken and deafened by the roar, that you begin to think that you could have been killed.

CNN: How did you cope with loneliness?

RKJ: I think people can either cope with loneliness or they can’t. In my case, because I was sailing a boat which requires full concentration, I never really had time to feel lonely for more than a few minutes as there was always something to do. When I got back 312 days after starting, I really was totally happy with my own company and had to adjust to being with people again.

CNN: What inspired you?

RKJ: A combination of boredom — I was first officer on a passenger ship and beginning to wonder if I really wanted to do that for the rest of my life — and the fact that Francis Chichester had just sailed around the world with one stop, thus leaving the last thing to be done: to go around alone and without a stop. Once I had thought of the idea it would not let me go.

CNN: How do you view nature?

RKJ: From watching the sun glittering on the sea in the Trades to working through huge icebergs, seeing the birds moving with the seasons; the miracle of spring; the puzzlement as to what caused the Big Bang and what was there before. I view it all with curiosity, respect and awe.

Dee Caffari

In 2009, the former British schoolteacher Dee Caffari became the first woman to sail solo and nonstop around the world — in both east and west directions.

That same year, Caffari and an all-female crew smashed the mono-hull speed record around Britain and Ireland, completing the voyage in six days.

The 40-year-old Briton is also the only woman to have circumnavigated the globe three times.

CNN: How did you cope with loneliness?

Dee Caffari: Prior to my first solo voyage I had never spent any length of time on my own — in fact I had never even lived alone, so it was quite a culture shock for me being at sea with just myself for company for six months. I think being busy and preoccupied with an activity is probably quite a good antidote to loneliness and when you sail solo there is always something to be done on-board. The one thing I really did miss was non-verbal communication. Until it is taken away, you don’t quite realize how much you pick up on from facial expressions and just being present.

CNN: What did you discover about yourself?

DC: I realized that however strong you think you are, when faced with adverse conditions you can always dig that little bit deeper and surprise yourself. On my first voyage I wasted emotional energy at times by getting frustrated and upset, mainly if I was tired or hungry. I learned that looking after myself physically had a huge impact on my emotional stability and once you know what the triggers are, you can learn to manage yourself better.

Read: Life of daredevil sailing photographer

CNN: What inspired you?

DC:My father was a strong influence on me and his encouragement to get on and do things instead of talking about them is a bit of a mantra for me in life. Of course, sailing legends such as Sir Peter Blake and Sir Chay Blyth have also been key figures that have inspired me in my career. When I am out on the water, I find that the elements themselves are inspirational.

CNN: How do you view nature?

DC: I am privileged to have sailed in some of the most remote environments on the planet and I have seen nature at its rawest and most hostile. I have also seen the most beautiful things like stunning sunsets, amazing wildlife, and even humans look pretty good after being at sea for six months!


Article source: http://edition.cnn.com/2013/05/16/travel/wisdom-from-the-sea/index.html?eref=edition

Article source: http://feedproxy.google.com/~r/NewsRipplesWeb/~3/lJCr6m76xBA/main-sail-react-fast-or-be-swept-away

Categories: Uncategorized Tags:

New York slaying considered hate crime

New York (CNN) — Police are investigating the slaying of a 32-year-old man in the Greenwich Village neighborhood early Saturday as a hate crime because the gunman made multiple anti-gay comments, they said.

It is the third violent attack in two weeks believed to be motivated by anti-gay bias, police said.

The suspect’s anti-gay remarks were noted before the shooting took place, Police Commissioner Raymond Kelly said. The man was seen urinating on the street outside a bar before going inside and making anti-gay comments to the bartender and brandishing a silver handgun.

A little after midnight, the gunman and two other companions confronted the victim, Marc Carson, and another man he was with on the street. The suspect reportedly made anti-gay remarks and asked them whether they were “gay wrestlers,” Kelly said.

Carson and the other man turned toward the taunts, but backed down and kept walking away. They didn’t know it, Kelly said, but the suspect followed them.

The gunman confronted the two men again, before shooting Carson in the face, police said.

Carson was pronounced dead on arrival at Beth Israel Hospital.

Around 4 a.m., a police officer, responding to a radio alert of the shooting, came across the alleged gunman and apprehended him. The suspect turned over a silver Taurus .38-caliber six-shot revolver, according to police.

Police later identified the suspect as Elliot Morales, 33. Police said the suspect had forged identification and they used facial recognition technology to determine his true identity.

Morales faces a charge of second-degree murder as a hate crime, authorities said.

The identities of the suspect’s two companions — at least one of whom Kelly said left the suspect before the shooting — are still not known.

Kelly said that the killing appeared to be “a hate crime, a bias crime.” There were no words that would aggravate the situation, and the victim did not know the perpetrator, he said.

According to Kelly, there have been 22 bias-motivated events this year. That’s up “significantly” from 13 this time last year.

On May 10, five men brutally beat two gay men near Madison Square Garden after the couple was denied entry into an after-hours billiards bar, according to Port Authority Police. The victims suffered severe facial injuries. Police were able to arrest two of the five men; the rest fled the scene.

There was another attack on gay men on May 5, outside of Madison Square Garden following a New York Knicks game. One of the victims told CNN affiliate WCBS he believes the attack wasn’t an isolated incident.

“There is no words to describe the pain, ’cause this was not an attack on us, this was an attack on all of us,” he said.

Kelly said authorities do not believe the acts are connected, but the investigations are ongoing.

“It’s not a pattern,” he said, “but something that concerns us.”

CNN’s Alcione Gonzalez contributed to this report.


Article source: http://edition.cnn.com/2013/05/18/justice/new-york-bias-attack/index.html?eref=edition

Article source: http://feedproxy.google.com/~r/NewsRipplesWeb/~3/QHb5GTofzZo/new-york-slaying-considered-hate-crime

Categories: Uncategorized Tags:

Cloning stem cells: What does it mean?

(CNN) — A human embryo, containing about a couple hundred cells, is smaller than the period at the end of a sentence. Scientists need strong microscopes to see these precursors to life, and to take from them stem cells, which have the potential to become any cell in the body.

Earlier this week a breakthrough in this field was announced. A group of researchers published in the journal Cell proof that they had created embryonic stem cells through cloning. The scientists produced embryos using human skin cells, and then used the embryos to produce stem cell lines.

“It is an incredibly powerful approach with potential to generate almost any tissue in the body, genetically identical to the patient,” said Jeff Karp, associate professor at Harvard Medical School and co-director of the Center for Regenerative Therapeutics at the Brigham and Women’s Hospital in Boston.

Creating an embryo just from an egg and a skin cell seems like magic, but just how practical would the subsequent stem cells be? And does it actually amount to cloning?

What they did

Normally, an embryo is created when sperm enters the egg and it starts to divide. But, in the Cell study, Shoukhrat Mitalipov and colleagues at Oregon Health and Sciences University began with skin cells from an 8-month-old baby that had a genetic disease. They did not use sperm.

To create each embryo, they took the DNA out of an egg, so that it was hollow, and replaced it with the skin cell’s DNA instead. The baby’s DNA was the only genetic material being used.

With the help of chemicals, the egg started to divide just like a normal fertilized egg would. Then, within several days, embryos genetically identical to the baby were created, from which stem cells were derived.


Understanding the stem cell breakthrough


Indian clinic’s stem cell therapy real?


Heart stem cells repair muscle damage

Embryonic stems research is inherently controversial because in order to use the stem cells for science, the embryo, which is a collection of cells that could develop into a fully formed human, is destroyed, even though embryos in these procedures are left over from in vitro fertilization.

However, Mitalipov said the embryos created in his study, from skin cells and eggs, would not grow babies. That would have required additional technology, and it wasn’t part of the study.

While cloning stem cells is a technical breakthrough, there’s already a method of deriving embryonic-like stem cells that doesn’t require the use of embryos at all: induced pluripotent stem (IPS) cells, said Dr. George Daley, who is director of the Stem Cell Transplantation Program at Children’s Hospital Boston and an international expert in stem cells.

Induced pluripotent stem cells can come from any cell in the human body, including skin cells, so they don’t have the moral quandaries surrounding them. Researchers have developed methods of inserting genes to “turn back the clock” on cells that have already specialized, so that they can turn into anything again. It doesn’t matter what the cell was before; it can now be reprogrammed as any kind of cell researchers want.

The new study involves a complex method that requires women to donate eggs, and a demanding manipulation of cell components on a tiny scale, Daley said.

What remains to be seen is whether these cloned embryonic stem cells are more useful therapeutically than the noncontroversial induced pluripotent stem cells, and questions linger about their effectiveness.

What’s the best type of stem cell

Ethical questions aside, researchers say they need to explore both embryonic and induced pluripotent stem cells in order to see what works best for various diseases and conditions.

Safety concerns linger around induced pluripotent stem cells because they were first created inserting four new genes.

“Remember, this was a genetic manipulation that was done to generate those cells, and there is concern that (for) anything you derive from them and you put back in the patient as graft, you may be at risk,” said John Gearhart, director of the Institute for Regenerative Medicine at the University of Pennsylvania, and one of the leading pioneers of stem cell research.

This image shows the donor egg cytoplasm, the substance that fills the cell, with the nucleus of the skin cell.

New techniques have been developed, however, to make induced pluripotent stem cells without permanent genetic modifications that were associated with tumors.

In mice, Daley and colleagues have shown that stem cells derived from the nuclear transfer of cells to make embryos — the technique described in Mitalipov’s paper — were indeed closer to natural embryo stem cells than induced pluripotent stem cells. The differences were so subtle that they may not be meaningful, however, he said.

Is it cloning?

The new study involves something similar to the cloning technique that led to the birth of Dolly, the famous cloned sheep that was born in July 1996. But making embryos for reproduction would require more advanced, complex techniques than were used in the new study — and serious scientists do not endorse human cloning for reproduction.

Mitalipov, senior author on the paper, laughs when asked if he wants to clone a person. “No, of course not,” he said.

“We tried the same approach to clone monkeys, because we’d been interested for biomedical research to produce cloned monkeys, and it never worked,” he said. “We’ve been working for a decade in that area.”

Mitalipov and colleagues had no intention of this research leading to the birth of a cloned human.

Researchers say there have been so many health problems in cloned animals, including Dolly herself, that it would not be ethical to attempt to create a cloned human.

“No legitimate scientist would be stepping forward to apply this in reproductive cloning, or for fertility work,” Daley said. “I would argue that really there are no good medical reasons to generate a cloned baby.”

So what is it good for?

There’s one important area where experts say Mitalipov’s method could have tremendous implications: Mitochondrial disease.

The mitochondria are the “power plants” of cells, supplying them with chemical energy. DNA in the mitochondria is inherited entirely from the mother’s egg, unlike the DNA in the cell’s nucleus, which comes from both parents.

Mutations in mitochondrial DNA can lead to deadly diseases, and their associated mutations are passed down to each new generation. Induced pluripotent stem cells preserve these harmful mutations, says Mitalipov.

A cell’s mitochondrial DNA develops mutations over the course of a lifetime, little by little, and may result in diseases such as Parkinson’s disease and diabetes, Milapotov said. It’s possible, he says, that one day there will be stem cell treatments for aging and age-related diseases.

The only way to ensure that stem cells derived from an adult patient do not have mitochondrial DNA mutations would be to use the technique demonstrated in the new study, Milapotov said: Creating embryos with cells from the patient’s own body, and healthy eggs, for the purpose of deriving embryonic stem cells.

“You want 0 miles in that rejuvenated cells that you want to put back into these patients,” he said. “The 0 mileage engine is in the egg.”

Mitalipov’s group also demonstrated in a 2012 Nature study that it could be possible to, using genetic techniques, reconstruct embryos that would not have the unhealthy mitochondrial mutations. This is not cloning, but draws on similar knowledge, and could cure a family’s genetic disease lineage in the future.

What’s next?

Daley estimates human clinical trials in stem cells will start within one to three years, but perhaps it could take a decade or more before the impact of stem cell therapy becomes widespread.

Gearhart is confident that the more we learn how to manipulate stem cells safely, there will be safe way to provide them to patients who need them. But there are different levels of risk for different uses. There will always be a risk-benefit calculation to be made, he said.

Different areas of stem cell research have proven to be harder than others. Beta cells for type I diabetes have been “a very difficult nut to crack,” Gearhart said, but there have been promising developments in repairing the heart, something that his lab has worked on, as well as for eye diseases.

“I think it’s going to be exciting times over the next several years when it comes to this,” he said.


Article source: http://edition.cnn.com/2013/05/18/health/stem-cells-cloning/index.html?eref=edition

Article source: http://feedproxy.google.com/~r/NewsRipplesWeb/~3/LBiSadtC49c/cloning-stem-cells-what-does-it-mean

Categories: Uncategorized Tags: